Article
Genetic effects influencing risk for major depressive disorder in China and Europe.
Translational psychiatry - 28 Mar 2017
Bigdeli T B, Ripke S, Peterson R E, Trzaskowski M, Bacanu S-A, Abdellaoui A, Andlauer T F M, Beekman A T F, Berger K, Blackwood D H R, Boomsma D I, Breen G, Buttenschøn H N, Byrne E M, Cichon S, Clarke T-K, Couvy-Duchesne B, Craddock N, de Geus E J C, Degenhardt F, Dunn E C, Edwards A C, Fanous A H, Forstner A J, Frank J, Gill M, Gordon S D, Grabe H J, Hamilton S P, Hardiman O, Hayward C, Heath A C, Henders A K, Herms S, Hickie I B, Hoffmann P, Homuth G, Hottenga J-J, Ising M, Jansen R, Kloiber S, Knowles J A, Lang M, Li Q S, Lucae S, MacIntyre D J, Madden P A F, Martin N G, McGrath P J, McGuffin P, McIntosh A M, Medland S E, Mehta D, Middeldorp C M, Milaneschi Y, Montgomery G W, Mors O, Müller-Myhsok B, Nauck M, Nyholt D R, Nöthen M M, Owen M J, Penninx B W J H, Pergadia M L, Perlis R H, Peyrot W J, Porteous D J, Potash J B, Rice J P, Rietschel M, Riley B P, Rivera M, Schoevers R, Schulze T G, Shi J, Shyn S I, Smit J H, Smoller J W, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert A M, Völzke H, Webb B T, Weissman M M, Wellmann J, Willemsen G, Witt S H, Levinson D F, Lewis C M, Wray N R, Flint J, Sullivan P F, Kendler K S
Abstract excerpt
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30-40%), extensive heterogeneity and a complex genetic architecture have complicated efforts to detect associated genetic risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE and PGC studies...
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