Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.

doi:10.1371/journal.pgen.0030213

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Article

Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.

PLoS genetics - 1 Nov 2007

Fernius Josefin, Hardwick Kevin G

Abstract excerpt

During cell division all chromosomes must be segregated accurately to each daughter cell. Errors in this process give rise to aneuploidy, which leads to birth defects and is implicated in cancer progression. The spindle checkpoint is a surveillance mechanism that ensures high fidelity of chromosome segregation by inhibiting anaphase until all kinetochores have established bipolar attachments to spindle...

Topics

Chromosome Positioning
Chromosome Segregation
Chromosomes, Fungal
Kinetochores
Microbial Viability
Microtubules
Mitosis
Mutation
Nocodazole
Nuclear Proteins
Protein Serine-Threonine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Protein Transport

Saccharomyces cerevisiae Proteins

Saccharomycetales

Spindle Apparatus

Tubulin Modulators

Source

Open in PubMed Open full text

Identifiers

PMID: 18081426
DOI: 10.1371/journal.pgen.0030213
PMCID: PMC2098806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18081426-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.PMID 18081426Read ↗

Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.Semantic proximity Read ↗

Bub3p facilitates spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle.Semantic proximity Read ↗

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.Semantic proximity Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.Semantic proximity Read ↗

Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.Semantic proximity Read ↗

Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis.Semantic proximity Read ↗

Distinct chromosome segregation roles for spindle checkpoint proteins.Semantic proximity Read ↗

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