Distinct chromosome segregation roles for spindle checkpoint proteins.

doi:10.1091/mbc.e02-04-0203

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Article

Distinct chromosome segregation roles for spindle checkpoint proteins.

Molecular biology of the cell - 1 Sept 2002

Warren Cheryl D, Brady D Michelle, Johnston Raymond C, Hanna Joseph S, Hardwick Kevin G, Spencer Forrest A

Abstract excerpt

The spindle checkpoint plays a central role in the fidelity of chromosome transmission by ensuring that anaphase is initiated only after kinetochore-microtubule associations of all sister chromatid pairs are complete. In this study, we find that known spindle checkpoint proteins do not contribute equally to chromosome segregation fidelity in Saccharomyces cerevisiae. Loss of Bub1 or Bub3 protein elicits the...

Topics

Alleles
Cell Cycle Proteins
Chromosome Segregation
Chromosomes
Fungal Proteins
Immunoblotting
Mutation
Nuclear Proteins
Phenotype
Plasmids
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Kinases

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 12221113
DOI: 10.1091/mbc.e02-04-0203
PMCID: PMC124140

Genes

BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12221113-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Distinct chromosome segregation roles for spindle checkpoint proteins.PMID 12221113Read ↗

BUB1 and BUBR1: multifaceted kinases of the cell cycle.Semantic proximity Read ↗

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1.Semantic proximity Read ↗

Bub1 regulates chromosome segregation in a kinetochore-independent manner.Semantic proximity Read ↗

Bub3p facilitates spindle checkpoint silencing in fission yeast.Semantic proximity Read ↗

The C-terminal half of Saccharomyces cerevisiae Mad1p mediates spindle checkpoint function, chromosome transmission fidelity and CEN association.Semantic proximity Read ↗

Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Semantic proximity Read ↗

Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.Semantic proximity Read ↗

Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.Semantic proximity Read ↗

Bub1p kinase activates the Saccharomyces cerevisiae spindle assembly checkpoint.Semantic proximity Read ↗

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.Semantic proximity Read ↗

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.Semantic proximity Read ↗

Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage.Semantic proximity Read ↗

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