Article
Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.
Molecular cell - 1 May 2003
Kitagawa Katsumi, Abdulle Rashid, Bansal Parmil K, Cagney Gerard, Fields Stanley, Hieter Philip
Abstract excerpt
The spindle checkpoint transiently prevents cell cycle progression of cells that have incurred errors or failed to complete steps during mitosis, including those involving kinetochore function. The molecular nature of the primary signal transmitted from defective kinetochores and how it is detected by the spindle checkpoint are unknown. We report biochemical evidence that Bub1, a component of the spindle...
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