Article
The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.
Science (New York, N.Y.) - 7 Jan 2005
Indjeian Vahan B, Stern Bodo M, Murray Andrew W
Abstract excerpt
Chromosome alignment on the mitotic spindle is monitored by the spindle checkpoint. We identify Sgo1, a protein involved in meiotic chromosome cohesion, as a spindle checkpoint component. Budding yeast cells with mutations in SGO1 respond normally to microtubule depolymerization but not to lack of tension at the kinetochore, and they have difficulty attaching sister chromatids to opposite poles of the spindle....
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