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Article

Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.

PloS one - 1 Jan 2015

Muñoz-Barrera Marta, Aguilar Isabel, Monje-Casas Fernando

Abstract excerpt

Aurora B and the spindle assembly checkpoint (SAC) collaborate to ensure the proper biorientation of chromosomes during mitosis. However, lack of Aurora B activity and inactivation of the SAC have a very different impact on chromosome segregation. This is most evident in Saccharomyces cerevisiae, since in this organism the lack of Aurora B is lethal and leads to severe aneuploidy problems, while the SAC is...

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Identifiers

PMID: 26661752
DOI: 10.1371/journal.pone.0144972
PMCID: PMC4682840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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