Article
Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle.
Current biology : CB - 6 Nov 2007
Indjeian Vahan B, Murray Andrew W
Abstract excerpt
BACKGROUND: Chromosomes must biorient on the mitotic spindle, with the two sisters attached to opposite spindle poles. The spindle checkpoint detects unattached chromosomes and monitors biorientation by detecting the lack of tension between two sisters attached to the same pole. After the spindle has been depolymerized and allowed to reform, budding yeast sgo1 mutants fail to biorient their sister chromatids and...
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