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Article

Bub3p facilitates spindle checkpoint silencing in fission yeast.

Molecular biology of the cell - 1 Dec 2009

Vanoosthuyse Vincent, Meadows John C, van der Sar Sjaak J A, Millar Jonathan B A, Hardwick Kevin G

Abstract excerpt

Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission yeast cells lacking Bub3p. Surprisingly, a robust mitotic arrest is maintained in the majority of bub3 Delta cells, yet they die, suggesting that Bub3p is essential...

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Source

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Identifiers

PMID: 19846658
DOI: 10.1091/mbc.e09-09-0762
PMCID: PMC2793287

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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