Article
Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.
Genetics - 1 Nov 2013
Ng Tessie M, Lenstra Tineke L, Duggan Nicole, Jiang Shuangying, Ceto Steven, Holstege Frank C P, Dai Junbiao, Boeke Jef D, Biggins Sue
Abstract excerpt
Accurate chromosome segregation requires that sister kinetochores biorient and attach to microtubules from opposite poles. Kinetochore biorientation relies on the underlying centromeric chromatin, which provides a platform to assemble the kinetochore and to recruit the regulatory factors that ensure the high fidelity of this process. To identify the centromeric chromatin determinants that contribute to chromosome...
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