Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.

Blood - 15 Feb 2008

Poncet Delphine, Belleville Aurélie, t'kint de Roodenbeke Claire, Roborel de Climens Aude, Ben Simon Elsa, Merle-Beral Hélène, Callet-Bauchu Evelyne, Salles Gilles, Sabatier Laure, Delic Jozo, Gilson Eric

Abstract excerpt

In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin prot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD19
Share to Gene Expression Profiling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Shelterin Complex

Share to Telomerase

Share to Telomere

Share to Telomere-Binding Proteins

Source

Identifiers

PMID: 18077792
DOI: 10.1182/blood-2007-09-111245

Genes

MRE11
POT1
RAD50
RPA1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18077792-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.PMID 18077792Read ↗

Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemiaSemantic proximity Read ↗

Telomere Dysfunction in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Regulation of Telomerase by Telomeric ProteinsSemantic proximity Read ↗

Telomere status in chronic lymphocytic leukemia with TP53 disruption.Semantic proximity Read ↗

The Relevance of Telomerase and Telomere-Associated Proteins in B-Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

TRF1 and TRF2: pioneering targets in telomere-based cancer therapySemantic proximity Read ↗

Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulationSemantic proximity Read ↗

RAP1/TERF2IP—A Multifunctional Player in Cancer DevelopmentSemantic proximity Read ↗

Telomere deregulations possess cytogenetic, phenotype, and prognostic specificities in acute leukemias.Semantic proximity Read ↗

The role of telomere binding molecules for normal and abnormal hematopoiesis.Semantic proximity Read ↗

Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes.Semantic proximity Read ↗

Telomere-Driven Checkpoint Remodeling Is Associated with Cytogenetic Risk in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.