Article
The role of telomere binding molecules for normal and abnormal hematopoiesis.
International journal of hematology - 1 Jun 2018
Hosokawa Kentaro, Arai Fumio
Abstract excerpt
In order to maintain the homeostasis of the hematopoietic system, hematopoietic stem cells (HSCs) need to be maintained while slowly dividing over their lifetime. However, repeated cell divisions lead to the gradual accumulation of DNA damage and ultimately impair HSC function. Since telomeres are particularly fragile when subjected to replication stress, cells have several defense machinery to protect telomeres....
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