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The Relevance of Telomerase and Telomere-Associated Proteins in B-Acute Lymphoblastic Leukemia

10 Mar 2023

Abstract excerpt

Telomeres and telomerase are closely linked to uncontrolled cellular proliferation, immortalization and carcinogenesis. Telomerase has been largely studied in the context of cancer, including leukemias. Deregulation of human telomerase gene hTERT is a well-established step in leukemia development. B-acute lymphoblastic leukemia (B-ALL) recovery rates exceed 90% in children; however, the relapse rate is around 20%...

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PMID: 36980962
DOI: 10.3390/genes14030691

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