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Article

Telomere status in chronic lymphocytic leukemia with TP53 disruption.

Oncotarget - 30 Aug 2016

Guièze Romain, Pages Mélanie, Véronèse Lauren, Combes Patricia, Lemal Richard, Gay-Bellile Mathilde, Chauvet Martine, Callanan Mary, Kwiatkowski Fabrice, Pereira Bruno, Vago Philippe, Bay Jacques-Olivier, Tournilhac Olivier, Tchirkov Andreï

Abstract excerpt

In chronic lymphocytic leukemia (CLL), telomere dysfunction is associated with poor outcomes. TP53 is involved in cellular responses to dysfunctional telomeres, and its inactivation is the strongest adverse prognostic factor for CLL. Given the biological relationship between TP53 and telomeres, and their prognostic value, it is important to improve our understanding of the impact of TP53 alterations on telomeres....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Serine Proteases

Share to Shelterin Complex

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Source

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Identifiers

PMID: 27486974
DOI: 10.18632/oncotarget.10927
PMCID: PMC5302966

Genes

POT1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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