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Regulation of Telomerase by Telomeric Proteins

1 Jun 2004

Abstract excerpt

Telomeres are essential for genome stability in all eukaryotes. Changes in telomere functions and the associated chromosomal abnormalities have been implicated in human aging and cancer. Telomeres are composed of repetitive sequences that can be maintained by telomerase, a complex containing a reverse transcriptase (hTERT in humans and Est2 in budding yeast), a template RNA (hTERC in humans and Tlc1 in yeast),...

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PMID: 15189140
DOI: 10.1146/annurev.biochem.73.071403.160049

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