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Article

Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation

25 Feb 2011

Abstract excerpt

Cells of B-cell chronic lymphocytic leukemia (B-CLL) are characterized by short telomeres despite a low proliferative index. Because telomere length has been reported to be a valuable prognosis criteria, there is a great interest in a deep understanding of the origin and consequences of telomere dysfunction in this pathology. Cases of chromosome fusion involving extremely short telomeres have been reported at...

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PMID: 21355086
DOI: 10.1182/blood-2010-07-295774

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