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Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia

4 Apr 2014

Abstract excerpt

Several studies have proposed telomere length and telomerase activity as prognostic factors in chronic lymphocytic leukemia (CLL), whereas information addressing the role of telomere-associated genes is limited. We measured relative telomere length (RTL) and TERT expression levels in purified peripheral CD19(+) B-cells from seven healthy donors and 77 untreated CLLs in early stage disease (Binet A). Data were...

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PMID: 24706380
DOI: 10.1002/gcc.22171

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