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Article

Telomere Dysfunction in Chronic Lymphocytic Leukemia

15 Jan 2021

Abstract excerpt

Telomeres are nucleprotein structures that cap the chromosomal ends, conferring genomic stability. Alterations in telomere maintenance and function are associated with tumorigenesis. In chronic lymphocytic leukemia (CLL), telomere length is an independent prognostic factor and short telomeres are associated with adverse outcome. Though telomere length associations have been suggested to be only a passive...

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Identifiers

PMID: 33520723
DOI: 10.3389/fonc.2020.612665

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