Article
Variants in the 5q31 cytokine gene cluster are associated with psoriasis.
Genes and immunity - 1 Mar 2008
Chang M, Li Y, Yan C, Callis-Duffin K P, Matsunami N, Garcia V E, Cargill M, Civello D, Bui N, Catanese J J, Leppert M F, Krueger G G, Begovich A B, Schrodi S J
Abstract excerpt
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis. Although the susceptibility effects at these SNPs were modest (joint allelic odds ratios (ORs): 0.76 to 0.78; P(comb): 1.3E-03 to 2.50E-04), the association patterns...
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