Article
Genetic variations in cytokines and cytokine receptors associated with psoriasis found by genome-wide association.
The Journal of investigative dermatology - 1 Apr 2009
Duffin Kristina Callis, Krueger Gerald G
Abstract excerpt
Genetic variants have long been suspected to be important in psoriasis. Recent work has suggested that HLA-Cw6 on chromosome 6 is the risk variant in the PSORS1 [MIM 177900] susceptibility locus that confers the greatest risk for early onset of psoriasis. Although numerous minor susceptibility loci have been identified by linkage analysis, few biologically relevant candidates have been discovered within these...
Topics
- Cytokines
- Genetic Predisposition to Disease
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Inflammatory Bowel Diseases
- Interleukin-12
- Interleukin-12 Subunit p40
- Interleukin-13
- Interleukin-15
- Interleukin-23
- Polymorphism, Single Nucleotide
- Psoriasis
- Receptors, Cytokine
- Receptors, Interleukin