A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

doi:10.1086/511051

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Article

A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.

American journal of human genetics - 1 Feb 2007

Cargill Michele, Schrodi Steven J, Chang Monica, Garcia Veronica E, Brandon Rhonda, Callis Kristina P, Matsunami Nori, Ardlie Kristin G, Civello Daniel, Catanese Joseph J, Leong Diane U, Panko Jackie M, McAllister Linda B, Hansen Christopher B, Papenfuss Jason, Prescott Stephen M, White Thomas J, Leppert Mark F, Krueger Gerald G, Begovich Ann B

Abstract excerpt

We performed a multitiered, case-control association study of psoriasis in three independent sample sets of white North American individuals (1,446 cases and 1,432 controls) with 25,215 genecentric single-nucleotide polymorphisms (SNPs) and found a highly significant association with an IL12B 3'-untranslated-region SNP (rs3212227), confirming the results of a small Japanese study. This SNP was significant in all...

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PMID: 17236132
DOI: 10.1086/511051
PMCID: PMC1785338

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