Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.

doi:10.1186/1475-2875-8-232

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Article

Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.

Malaria journal - 19 Oct 2009

Naka Izumi, Nishida Nao, Patarapotikul Jintana, Nuchnoi Pornlada, Tokunaga Katsushi, Hananantachai Hathairad, Tsuchiya Naoyuki, Ohashi Jun

Abstract excerpt

BACKGROUND: It has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a...

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PMID: 19840389
DOI: 10.1186/1475-2875-8-232
PMCID: PMC2770543

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