Article
Fine mapping of eight psoriasis susceptibility loci.
European journal of human genetics : EJHG - 1 Jun 2015
Das Sayantan, Stuart Philip E, Ding Jun, Tejasvi Trilokraj, Li Yanming, Tsoi Lam C, Chandran Vinod, Fischer Judith, Helms Cynthia, Duffin Kristina Callis, Voorhees John J, Bowcock Anne M, Krueger Gerald G, Lathrop G Mark, Nair Rajan P, Rahman Proton, Abecasis Goncalo R, Gladman Dafna, Elder James T
Abstract excerpt
Previous studies have identified 41 independent genome-wide significant psoriasis susceptibility loci. After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling genotyping of 2269 single-nucleotide polymorphisms (SNPs) in the...
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