Article
Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking.
The Journal of investigative dermatology - 1 Dec 2009
Duffin Kristina Callis, Freeny Ingrid C, Schrodi Steven J, Wong Bob, Feng Bing-Jian, Soltani-Arabshahi Razieh, Rakkhit Tina, Goldgar David E, Krueger Gerald G
Abstract excerpt
Genetic and environmental factors influence the development of psoriasis (Ps) and psoriatic arthritis (PsA). Recently, we reported that three IL13 polymorphisms, rs1800925, rs20541, and rs848, on chromosome 5q31 conferred the risk for Ps. IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma. Further, smoking may increase the risk of developing Ps. We examined the association between...