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Article

Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.

Cancer research - 1 Dec 2007

Kang Jin Seok, Wanibuchi Hideki, Morimura Keiichirou, Gonzalez Frank J, Fukushima Shoji

Abstract excerpt

CYP2E1 metabolizes many low-molecular weight toxins and carcinogens. Some in vitro experiments suggest that CYP2E1 may be involved in the metabolic activation of diethylnitrosamine. However, there has been no direct evidence demonstrating a role for CYP2E1 in diethylnitrosamine-mediated carcinogenesis in vivo. To clarify this, we carried out a diethylnitrosamine-induced hepatocarcinogenesis experiment using...

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Source

Identifiers

PMID: 18056438
DOI: 10.1158/0008-5472.CAN-07-1369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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