Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.

Hepatology (Baltimore, Md.) - 1 Sept 2015

Zavattari Patrizia, Perra Andrea, Menegon Silvia, Kowalik Marta Anna, Petrelli Annalisa, Angioni Maria Maddalena, Follenzi Antonia, Quagliata Luca, Ledda-Columbano Giovanna Maria, Terracciano Luigi, Giordano Silvia, Columbano Amedeo

Abstract excerpt

UNLABELLED: Hepatocellular carcinoma (HCC) develops through a multistage process, but the nature of the molecular changes associated with the different steps, the very early ones in particular, is largely unknown. Recently, dysregulation of the NRF2/KEAP1 pathway and mutations of these genes have been observed in experimental and human tumors, suggesting their possible role in cancer development. To assess...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular

Share to Liver Neoplasms, Experimental

Share to NF-E2-Related Factor 2

Share to Random Allocation

Share to Rats, Inbred F344

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 25783764
DOI: 10.1002/hep.27790

Genes

KEAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis.PMID 25783764Read ↗

Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC.Semantic proximity Read ↗

Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.Semantic proximity Read ↗

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of TumourigenesisSemantic proximity Read ↗

Liver carcinogenesis: from naughty chemicals to soothing fat and the surprising role of NRF2.Semantic proximity Read ↗

Different inhibition of Nrf2 by two Keap1 isoforms α and β to shape malignant behaviour of human hepatocellular carcinomaSemantic proximity Read ↗

Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma.Semantic proximity Read ↗

NRF2 co-opts the SWI/SNF complex to drive liver cell plasticitySemantic proximity Read ↗

Genomic and transcriptomic analyses of chemical hepatocarcinogenesis aggravated by oncoprotein lossSemantic proximity Read ↗

NRF2 DLG Domain Mutations Identified in Japanese Liver Cancer Patients Affect the Transcriptional Activity in HCC Cell Lines.Semantic proximity Read ↗

Oncogenic Activation of Nrf2, Though as a Master Antioxidant Transcription Factor, Liberated by Specific Knockout of the Full-Length Nrf1α that Acts as a Dominant Tumor RepressorSemantic proximity Read ↗

Nrf1 is endowed with a dominant tumor-repressing effect onto the Wnt/β-Catenin-dependent and -independent signaling networks in the human liver cancerSemantic proximity Read ↗

Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.