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Article

Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Sept 2014

Matsushita Kohei, Kuroda Ken, Ishii Yuji, Takasu Shinji, Kijima Aki, Kawaguchi Hiroaki, Miyoshi Noriaki, Nohmi Takehiko, Ogawa Kumiko, Nishikawa Akiyoshi, Umemura Takashi

Abstract excerpt

We have developed a new medium-term animal model, "GPG", in which an in vivo mutation assay in partially hepatectomized tissue and a tumor-promoting assay were performed. The tumor-promoting assay measures glutathione S-transferase placental form positive foci induced by diethylnitrosamine (DEN) in the residual tissue. Given that a limitation of the original protocol is the potential interaction between the test...

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Identifiers

PMID: 24929978
DOI: 10.1016/j.etp.2014.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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