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Article

Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci.

The American journal of pathology - 1 May 2002

Pierce Robert H, Vail Mary E, Ralph Leah, Campbell Jean S, Fausto Nelson

Abstract excerpt

Tumor development is thought to require both increased proliferation and inhibition of apoptosis. However, the relationship between cell replication and cell death in liver tumorigenesis is complex because both proliferation and apoptosis increase during hepatocarcinogenesis. To investigate the effect of the anti-apoptotic gene Bcl-2 in liver carcinogenesis, we established a line of double transgenic mice that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12000706
DOI: 10.1016/S0002-9440(10)61101-7
PMCID: PMC1850870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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