Article
Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice.
Communications biology - 21 Jan 2022
Nakano Yasuhiro, Nakao Sachie, Sueoka Minako, Kasahara Daigo, Tanno Yuri, Sumiyoshi Hideaki, Itoh Tohru, Miyajima Atsushi, Hozumi Katsuto, Inagaki Yutaka
Abstract excerpt
Notch signaling is one of the most common drivers of carcinogenesis in many types of cancers, including hepatocellular carcinoma (HCC); however, it occasionally suppresses tumor progression. Moreover, it is virtually unknown how different sets of Notch ligands and receptors regulate the HCC development. In this study, we demonstrate that the expression of the Notch ligands, Delta-like 4 (Dll4) and Jagged-1...
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