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Article

Augmentation of diethylnitrosamine-induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine.

Drug and chemical toxicology - 1 Nov 2019

Punvittayagul Charatda, Chariyakornkul Arpamas, Chewonarin Teera, Jarukamjorn Kanokwan, Wongpoomchai Rawiwan

Abstract excerpt

Diethylnitrosamine (DEN) and 1,2-dimethylhydrazine (DMH) are classical carcinogens used in experimental rodent carcinogenesis. However, the interaction effects of these carcinogens on biochemical and molecular changes during carcinogenesis have not been investigated. Therefore, the effect of DEN and DMH co-administration on preneoplastic lesion formation and its molecular mechanism in rats were determined. Triple...

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Identifiers

PMID: 29722557
DOI: 10.1080/01480545.2018.1464019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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