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Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma

4 May 2004

Abstract excerpt

Cytochrome P450-2E1 (CYP2E1) is one of the major hepatic enzymes involved in the metabolism of procarcinogen. Our study aimed to investigate the differential expression level of CYP2E1 and its clinicopathological significance in hepatocellular carcinoma (HCC). CYP2E1 revealed low level of expression in 70% of the tumor tissues, when compared to the adjacent nontumor tissues, at both mRNA and protein levels. The...

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PMID: 15239125
DOI: 10.1002/ijc.20282

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