Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.

Nature immunology - 1 Jan 2005

Roldán Esther, Fuxa Martin, Chong Winnie, Martinez Dolores, Novatchkova Maria, Busslinger Meinrad, Skok Jane A

Abstract excerpt

Allelic exclusion of immunoglobulin genes ensures the expression of a single antibody molecule in B cells through mostly unknown mechanisms. Large-scale contraction of the immunoglobulin heavy-chain (Igh) locus facilitates rearrangements between Igh variable (V(H)) and diversity gene segments in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Mice, Transgenic

Source

Open in PubMed Open full text

Identifiers

PMID: 15580273
DOI: 10.1038/ni1150
PMCID: PMC1592471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15580273-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.PMID 15580273Read ↗

Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation.Semantic proximity Read ↗

MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUSSemantic proximity Read ↗

Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus.Semantic proximity Read ↗

Immunoglobulin locus silencing and allelic exclusion.Semantic proximity Read ↗

Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.Semantic proximity Read ↗

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.Semantic proximity Read ↗

Locus Suicide Recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissuesSemantic proximity Read ↗

Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.Semantic proximity Read ↗

Dynamic regulation of antigen receptor gene assembly.Semantic proximity Read ↗

Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion.Semantic proximity Read ↗

Contribution of the IGCR1 regulatory element and the 3 <i>’Igh</i> CBEs to Regulation of <i>Igh</i> V(D)J RecombinationSemantic proximity Read ↗

The IgH locus 3' cis-regulatory super-enhancer co-opts AID for allelic transvection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.