Article
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.
The Journal of investigative dermatology - 1 Jun 2008
Novak Natalija, Baurecht Hansjörg, Schäfer Torsten, Rodriguez Elke, Wagenpfeil Stefan, Klopp Norman, Heinrich Joachim, Behrendt Heidrun, Ring Johannes, Wichmann Erich, Illig Thomas, Weidinger Stephan
Abstract excerpt
Allergic contact dermatitis is one of the most frequent dermatological problems affecting 7% of the general population. Impaired skin barrier function facilitates the penetration of contact allergens and irritants into the epidermal layer and is regarded as an important cofactor promoting the process of allergic contact sensitization. Filaggrin is crucial for the maintenance of the skin barrier function....
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