Article
Nickel sensitization, hand eczema, and loss-of-function mutations in the filaggrin gene.
Dermatitis : contact, atopic, occupational, drug - 1 Jan 2000
Thyssen Jacob Pontoppidan, Carlsen Berit Christina, Menné Torkil
Abstract excerpt
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease. Recently, it was demonstrated that a large proportion of individuals with AD have an epidermal expression deficiency of filaggrin (FLG). This unique finding may have great implications for our understanding of nickel sensitization because nickel is chelated in the epidermis and perhaps to FLG. This review aims to briefly present the current...
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