Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.

doi:10.1016/j.jaci.2006.05.004

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Article

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.

The Journal of allergy and clinical immunology - 1 Jul 2006

Weidinger Stephan, Illig Thomas, Baurecht Hansjörg, Irvine Alan D, Rodriguez Elke, Diaz-Lacava Amalia, Klopp Norman, Wagenpfeil Stefan, Zhao Yiwei, Liao Haihui, Lee Simon P, Palmer Colin N A, Jenneck Claudia, Maintz Laura, Hagemann Tobias, Behrendt Heidrun, Ring Johannes, Nothen Markus M, McLean W H Irwin, Novak Natalija

Abstract excerpt

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong genetic background. One of the characteristic features of AD and causative factor for the disease is an impaired epidermal skin barrier based on a primary defect of epidermal differentiation. OBJECTIVES: Recently, 2 loss-of-function mutations (R501X and 2282derl4) in the filaggrin gene (FLG) that cause ichthyosis vulgaris, one...

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PMID: 16815158
DOI: 10.1016/j.jaci.2006.05.004

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