Article
Filaggrin in atopic dermatitis.
The Journal of allergy and clinical immunology - 1 Oct 2008
O'Regan Grainne M, Sandilands Aileen, McLean W H Irwin, Irvine Alan D
Abstract excerpt
The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light on disease mechanisms in eczema, a disease that had heretofore largely been considered to have a primarily immunologic etiopathogenesis. The filaggrin gene (FLG) mutation findings are consistent with a recently proposed unifying hypothesis that offers a...
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