Article
Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2001
Welch C L, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang C P, Barlow C, Dansky H, Breslow J L, Tall A R
Abstract excerpt
Atherosclerosis is a complex disease resulting from the interaction of multiple genes. We have used the Ldlr knockout mouse model in an interspecific genetic cross to map atherosclerosis susceptibility loci. A total of 174 (MOLF/Ei x B6.129S7-Ldlr(tm1Her)) x C57BL/6J-Ldlr(tm1Her) backcross mice, homozygous for the Ldlr null allele, were fed a Western-type diet for 3 months and then killed for quantification of...
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