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Article

A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.

Nature cell biology - 1 Feb 2008

Aulehla Alexander, Wiegraebe Winfried, Baubet Valerie, Wahl Matthias B, Deng Chuxia, Taketo Makoto, Lewandoski Mark, Pourquié Olivier

Abstract excerpt

Rhythmic production of vertebral precursors, the somites, causes bilateral columns of embryonic segments to form. This process involves a molecular oscillator--the segmentation clock--whose signal is translated into a spatial, periodic pattern by a complex signalling gradient system within the pr...

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Identifiers

PMID: 18157121
DOI: 10.1038/ncb1679
PMCID: PMC7391962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18157121-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.PMID 18157121Read ↗

Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.Semantic proximity Read ↗

Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation.Semantic proximity Read ↗

<i>In vitro</i> characterization of the human segmentation clockSemantic proximity Read ↗

Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC.Semantic proximity Read ↗

Synchrony dynamics during initiation, failure, and rescue of the segmentation clock.Semantic proximity Read ↗

<i>Fgf4</i> is critical for maintaining <i>Hes7</i> levels and Notch oscillations in the somite segmentation clockSemantic proximity Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.Semantic proximity Read ↗

Disruption of the somitic molecular clock causes abnormal vertebral segmentation.Semantic proximity Read ↗

Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis.Semantic proximity Read ↗

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