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Article

Severe phenytoin toxicity in a CYP2C933 homozygous mutant from India.

Neurology India - 1 Jan 2000

Ramasamy Kesavan, Narayan Sunil K, Chanolean Shashindran, Chandrasekaran Adithan

Abstract excerpt

The authors report an Indian adult female patient with a history of generalized tonic clonic seizures who developed severe features of phenytoin (DPH) toxicity on therapeutic dosage of this antiepileptic drug. Administration of 300 mg/day of DPH in this patient resulted in toxic symptoms associated with an excessive serum DPH concentration of 33 microg/ml. The PCR-RFLP analysis revealed a homozygosity involving...

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Share to Anticonvulsants
Share to Aryl Hydrocarbon Hydroxylases
Share to Cytochrome P-450 CYP2C9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Generalized

Share to Phenytoin

Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 18040121
DOI: 10.4103/0028-3886.33300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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