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Article

CYP2C9 polymorphism in patients with epilepsy: genotypic frequency analyzes and phenytoin adverse reactions correlation.

Arquivos de neuro-psiquiatria - 1 Apr 2011

Twardowschy Carlos Alexandre, Werneck Lineu César, Scola Rosana Herminia, De Paola Luciano, Silvado Carlos Eduardo

Abstract excerpt

OBJECTIVE: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism observed in the corresponding gene may affect therapeutic outcome during treatment. The distribution of variant CYP2C9 alleles and prevalence of phenytoin adverse reactions were hereby investigated in a population of patients diagnosed with epilepsy. METHOD: Allele-specific PCR analysis was carried out in order to determine...

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Identifiers

PMID: 21537551
DOI: 10.1590/s0004-282x2011000200002

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