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Article

Association analysis of CYP2C9*3 and phenytoin-induced severe cutaneous adverse reactions (SCARs) in Thai epilepsy children.

Journal of human genetics - 1 Aug 2015

Suvichapanich Supharat, Jittikoon Jiraphun, Wichukchinda Nuanjun, Kamchaisatian Wasu, Visudtibhan Anannit, Benjapopitak Suwat, Nakornchai Somjai, Manuyakorn Wiparat, Mahasirimongkol Surakameth

Abstract excerpt

CYP2C9 is the key enzyme in aromatic antiepileptic drugs (AEDs) metabolism. CYP2C9*3 is a loss of function polymorphism. This study was designed to investigate genetic association between CYP2C9*3 and aromatic AED-induced severe cutaneous adverse reactions (SCARs) in Thai children. The 37 aromatic AED-induced SCARs patients (20 phenobarbital and 17 phenytoin) and 35 tolerances (19 phenobarbital and 16 phenytoin)...

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Identifiers

PMID: 25994870
DOI: 10.1038/jhg.2015.47

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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