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Article

CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment

1 Mar 2018

Abstract excerpt

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and status epilepticus, and effective in controlling focal seizures with and without tonic-clonic generalization and status epilepticus. The metabolization of PHT is carried out by two oxidative cytochrome P450 enzymes CYP2C9 and CYP2C19; 90% of this metabolization is done by CYP2C9 and the remaining 10% by CYP2C19. Genetic...

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Drug Transport and Resistance Mechanisms
Pharmacogenetics and Drug Metabolism
Pharmacological Effects and Toxicity Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29636628
DOI: 10.2147/pgpm.s108113

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