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Article

Frequencies of CYP2C9 polymorphisms in North Indian population and their association with drug levels in children on phenytoin monotherapy.

BMC pediatrics - 14 May 2016

Chaudhary Nagendra, Kabra Madhulika, Gulati Sheffali, Gupta Yogendra Kumar, Pandey Ravindra Mohan, Bhatia Bal Dev

Abstract excerpt

BACKGROUND: Phenytoin, mainly metabolized by cytochrome P450 enzyme system, has a narrow therapeutic index and may have adverse effects due to inter-individual variation in the dose requirement and genetic polymorphisms. This cross-sectional study was done to study the prevalence of cytochrome P450 CYP2C9 polymorphisms in Indian epileptic children and to see the effect of polymorphisms on serum levels in...

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Identifiers

PMID: 27179628
DOI: 10.1186/s12887-016-0603-0
PMCID: PMC4868001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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