Article
A common genetic basis for idiosyncratic toxicity of warfarin and phenytoin.
Epilepsy research - 1 Jul 1999
Rettie A E, Haining R L, Bajpai M, Levy R H
Abstract excerpt
CYP2C9 is mainly responsible for the metabolic clearance of phenytoin and (S)-warfarin. We have shown previously that mutations in the CYP2C9 gene are associated with diminished metabolism of (S)-warfarin, and so we have now studied the metabolism of phenytoin to its primary inactive metabolite, (S)-pHPPH, by these mutant enzymes. Kinetic parameters were determined for (S)-pHPPH formation using recombinant CYP2C9...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.