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Article

Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis.

Journal of clinical pharmacy and therapeutics - 1 Jun 2018

Wu X, Liu W, Zhou W

Abstract excerpt

WHAT IS KNOWN AND OBJECTIVE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that can be induced by phenytoin (PHT). CYP2C9*3 is the key enzyme in PHT metabolism. The aim of this meta-analysis was to evaluate the association between CYP2C9*3 and PHT-induced SJS/TEN. METHODS: An extensive search was performed in multiple databases, including the Cochrane...

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PMID: 29274302
DOI: 10.1111/jcpt.12660

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