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Article

Acenocoumarol and phenytoin toxicity in the presence of CYP2C9 mutation.

The Journal of the Association of Physicians of India - 1 Apr 2008

Jose Linda, Binila Chacko, Chandy S J, Mathews J E, Mathews K P

Abstract excerpt

This case report describes a rare interaction between therapeutic doses of phenytoin and acenocoumarol resulting in both acute phenytoin toxicity and increased international normalized ratio (INR). Interactions between these drugs are due to the pharmacokinetics and the common metabolising pathway by hepatic cytochrome P450 isoenzyme-CYP2C9. Our patient was detected to be homozygous for CYP2C9*3 by PCR-RFLP...

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Source

Identifiers

PMID: 18702389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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