Article
Severe phenytoin intoxication in a subject homozygous for CYP2C9*3.
Clinical pharmacology and therapeutics - 1 Oct 2001
Brandolese R, Scordo M G, Spina E, Gusella M, Padrini R
Abstract excerpt
A 31-year-old woman who had a severe head injury was treated with oral phenytoin (100 mg 3 times a day) to prevent posttraumatic seizures. On day 10 of phenytoin treatment, 3 hours after the morning dose, the patient manifested neurologic signs compatible with phenytoin intoxication. Thus drug serum concentrations were monitored daily for 12 days. The elimination half-life was 103 hours, namely, about 5 times...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.