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Article

A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1.

BMC cancer - 29 Dec 2015

Canal Frédéric, Anthony Elodie, Lescure Aurianne, Del Nery Elaine, Camonis Jacques, Perez Franck, Ragazzon Bruno, Perret Christine

Abstract excerpt

BACKGROUND: Aberrant activation of the Wnt/β-catenin pathway is a major and frequent event in liver cancer, but inhibition of oncogenic β-catenin signaling has proven challenging. The identification of genes that are synthetically lethal in β-catenin-activated cancer cells would provide new targets for therapeutic drug design. METHODS: We transfected the parental HuH6 hepatoblastoma cell line with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26715116
DOI: 10.1186/s12885-015-2037-8
PMCID: PMC4696130

Genes

CTNNB1
HGS
BRAF
FES
PKMYT1
STRADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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