Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation.

Cancer letters - 1 Feb 2014

Lee Jung Min, Yang Jing, Newell Pippa, Singh Sucha, Parwani Anil, Friedman Scott L, Nejak-Bowen Kari Nichole, Monga Satdarshan P

Abstract excerpt

β-Catenin signaling is implicated in hepatocellular carcinoma (HCC), although its role in inflammation, fibrosis, and proliferation is unclear. Commercially available HCC tissue microarray (TMA) of 89 cases was assessed for β-catenin, one of its transcriptional targets glutamine synthetase (GS), proliferation (PCNA), inflammation (CD45), and fibrosis (Sirius Red). HCC cells transfected with wild-type (WT) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to DNA Methylation

Share to Fibrosis

Share to Glutamate-Ammonia Ligase

Share to Inflammation

Share to Liver Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24071572
DOI: 10.1016/j.canlet.2013.09.020
PMCID: PMC3874258

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β-Catenin signaling in hepatocellular cancer: Implications in inflammation, fibrosis, and proliferation.PMID 24071572Read ↗

Exploring the Impact of the β-Catenin Mutations in Hepatocellular Carcinoma: An In-Depth Review.Semantic proximity Read ↗

β‐catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β‐catenin and METSemantic proximity Read ↗

Impact of Aberrant β-Catenin Pathway on Cholangiocarcinoma HeterogeneitySemantic proximity Read ↗

Genotype-phenotype correlation of CTNNB1 mutations reveals different ß-catenin activity associated with liver tumor progression.Semantic proximity Read ↗

Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.Semantic proximity Read ↗

β-catenin alteration is rare in hepatocellular carcinoma with steatohepatitic features: immunohistochemical and mutational study.Semantic proximity Read ↗

Liver Zonation Disruption Fuels Hepatocellular Carcinoma in Chronic Liver DiseaseSemantic proximity Read ↗

Hepatocellular Adenomas: Morphology and Genomics.Semantic proximity Read ↗

siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival.Semantic proximity Read ↗

Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.Semantic proximity Read ↗

Malignant transformation of a β-catenin inflammatory adenoma due to an S45 β-catenin-activating mutation present 12 years before.Semantic proximity Read ↗

Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.