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Article

ShRNA-mediated gene silencing of β-catenin inhibits growth of human colon cancer cells

1 Jan 2007

Abstract excerpt

AIM: To observe the gene silencing mediated by the specific shRNA targeted against beta-catenin and its effect on cell proliferation and cycle distribution in the human colon cancer cell line Colo205. METHODS: Two shRNA plasmid vectors against beta-catenin were constructed and transfected into Colo205 cells with Lipofectamine2000. The down-regulations of beta-catenin, c-myc and cyclinD1 expressions were detected...

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PMID: 18161931
DOI: 10.3748/wjg.v13.i48.6581

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