Article
Covert genetic selections to optimize phenotypes.
PloS one - 21 Nov 2007
Wu Di, Townsley Elizabeth, Tartakoff Alan Michael
Abstract excerpt
In many high complexity systems (cells, organisms, institutions, societies, economies, etc.), it is unclear which components should be regulated to affect overall performance. To identify and prioritize molecular targets which impact cellular phenotypes, we have developed a selection procedure ("SPI"-single promoting/inhibiting target identification) which monitors the abundance of ectopic cDNAs. We have used...
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